Protein sorting: Recognizing mitochondrial presequences
نویسنده
چکیده
The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.
منابع مشابه
Minireview : Mitochondrial Presequences 4511
The discovery that proteins imported from the cytoplasm into mitochondria are usually synthesized as larger precursors (Maccecchini et al., 1979) has focussed attention on the function of targeting sequences in mitochondrial biogenesis. AS protein sorting within a cell is being elucidated, it becomes clear that mitochondria utilize a unique mechanism for the specific targeting and uptake of the...
متن کاملRefining the definition of plant mitochondrial presequences through analysis of sorting signals, N-terminal modifications, and cleavage motifs.
Mitochondrial protein import is a complex multistep process from synthesis of proteins in the cytosol, recognition by receptors on the organelle surface, to translocation across one or both mitochondrial membranes and assembly after removal of the targeting signal, referred to as a presequence. In plants, import has to further discriminate between mitochondria and chloroplasts. In this study, w...
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The mitochondrial inner membrane is a highly protein-rich membrane with central importance for oxidative phosphorylation and metabolite transport. A large number of inner-membrane proteins are synthesized as preproteins with cleavable presequences. Opposing mechanisms of preprotein insertion into the membrane have been debated: stop-transfer with arrest in the inner membrane versus conservative...
متن کاملMultiple pathways for sorting mitochondrial precursor proteins.
Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino-terminal presequences, but instead contain different types of internal targeting signals. Recent studies have revealed an unexpected complexity of the mitochondrial protein import machinery and have led to the disc...
متن کاملMitochondrial protein import.
Most mitochondrial proteins are synthesized as precursor proteins on cytosolic polysomes and are subsequently imported into mitochondria. Many precursors carry amino-terminal presequences which contain information for their targeting to mitochondria. In several cases, targeting and sorting information is also contained in non-amino-terminal portions of the precursor protein. Nucleoside triphosp...
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عنوان ژورنال:
- Current Biology
دوره 10 شماره
صفحات -
تاریخ انتشار 2000